Effects of CBD Oil on Your Liver – Is Cannabidiol Bad?

You might be familiar that approximately 30 million Americans have liver disease, and it has become the 12^th most common cause of death in the US. The liver is the most essential body organ that cleans the blood, processes, and detoxifies harmful substances. On the flip side, researchers are studying the root cause of liver disease. A new study shows that liver damage may result from the effects of CBD oil on your liver. Well, the research is in its early stages.

The market of CBD products – the non-intoxicant and pain-relieving chemical of the cannabis plant has exploded in a few recent years. The unregulated CBD market makes it a little daunting. Moreover, a new study found that excessive use of CBD can cause liver damage.

Being a CBD user, your might be worried about it. Fret not! We will look at the study and reports of liver toxicity with CBD usage.

Let us look at the evidence!

What the Study Says:

Researchers from the University of Arkansas investigate the effects of treatment of various CBD dosages on the users. They conclude that the lack of comprehensive studies and unregulating the CBD market causes problems.

Overall the mice tolerated CBD dosages. However, higher doses – a human equivalent to 200mg of CBD per kilogram of the bodyweight of CBD – showed clear signs of liver toxicity.

Furthermore, the repeated small doses of CBD – equivalent to 50mg of CBD also show signs of liver swelling and damage.

Do not worry too much! Some experts point out that patients must know the amount of cannabidiol, the risk, and the fact that the amount of CBD used in research studies is far higher than what humans take. However, it does not mean that you can take a higher CBD dosage. As you know that the excessive use of ibuprofen or Tylenol has determinantal consequences. In general, CBD is not different from these medications. The therapeutic doses of CBD range from 0.5 – 20 mg/kg per day. Similar to other medications, you must be aware of the doses you consume.

Moreover, some researchers report that mice and humans are pretty different. In addition, they said that extrapolation of this research shows that a daily dosage of 20mg has no negative effects on humans.

The Dosing Problem:

Sticking to the right CBD dosage appears to be safe for the time being. But it does not mean that CBD users are risk-free. Currently, the whole CBD market has no regulations for dosage. So, a person can take more or less cannabidiol than advertised on the product.

However, FDA has sent warning letters to those companies selling inaccurate levels of the compound. The companies and brands that make unnecessary health claims also receive lawsuits from FDA.

Right now the primary need of the market is accreditation for all tests and traceability and the introduction of stability testing and shelf labeling like the FDA requires for all food products and supplements.

CBD Interaction With Prescribed Medications:

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The primary concern with CBD is its interaction with prescribed medications. CBD is metabolized by the enzyme CYP3A4. The prescribed medications that hinder the CYP3A4 can slow down the breakdown of CBD and increase the rate of physiological activity. Other drugs may increase the levels of enzymes for the rapid breakdown of CBD.

Moreover, CBD interacts with cytochrome P450 enzymes that metabolize several pharmaceuticals. The high doses of CBD inactivate cytochrome P450 that leads to toxic levels of pharmaceutical drugs.

Because of these concerns, it is necessary to consult with a health care professional before taking CBD. You can avoid cannabidiol with those medications that contain Grapefruit Warning.

Effects of CBD Oil on Your Liver:

A 2019 study showed that CBD led to the elevation of liver enzymes at high levels. And, it is an indicator of liver damage. However, the CBD dosage used in the research was high. No data is yet available on liver damage after using cannabidiol.

Nonetheless, the relationship between CBD and the liver is not all doom and gloom. It should be noted that the lower doses of cannabidiol are effective and protective against alcohol-induced liver damage. Moreover, some researchers found that CBD is effective in treating liver damage with inflammation, oxidative stress, and steatosis.

Quality of CBD Matters:

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In addition to CBD concerns and interactions with drugs, ensuring the quality of CBD products is crucial. Whether you are buying CBD for the first time or a professional user, be sure to ask yourself the following questions.

1. Is the company well-established?

Take some time to do quality research before opting for any product. Numerous brands and companies are offering CBD products, but all are of not the same quality. It is essential to inform yourself that you are getting a quality product from a trusted buyer. A well-established brand passes each product batch from a third-party lab to ensure safety. Moreover, the lab report shows the types of ingredients and their precise concentrations.

2. Does it post the result of 3^rd party lab report on the website?

All reputable and trusted brands exhibit the lab testing report on their website. Or the customer can demand the lab report. If your selected company does not provide a lab report, avoid it. Some companies upload the lab report on their official websites some others give a QR code for scanning. When checking the lab report, be sure to verify the absence of pesticides, herbicides, and other unwanted compounds.

3. How does it extract cannabidiol?

You might be familiar with the CBD extraction process. All the high-quality brands use the CO₂ extraction method to preserve the effectiveness of cannabidiol. Besides CO₂ extraction, some companies use solvent extraction in which the quality does not remain the same.

4. Is CBD oil free from pesticides, insecticides, and heavy metals?

Generally, CBD comes from the hemp plant that is a bio-accumulator. It can attract everything from the surrounding environment. A quality CBD oil extracted through the CO₂ extraction method and passed through 3^rd party lab does not contain these unwanted substances.

5. Does the company outline its extraction process?

Believe it or not, some companies in the market are failing to mention the extraction process. When scanning through a brand’s website, if you find nothing explaining the extraction and manufacturing process, avoid buying from them.

6. Where does it source cannabis or hemp?

Another crucial thing that determines the quality and effects of CBD oil on your liver is the hemp source. Hemp is the primary source of cannabidiol. CBD oil sourced from industrial hemp has high quality. Furthermore, hemp grown in the US and EU are of high quality as it has grown under high guidelines.

Final Thoughts on the Effects of CBD Oil on Your Liver:

While the FDA works on improving its oversight and regulatory structure, the best thing a consumer CBD user can do is buy from a marketplace that offers transparent laboratory testing, possibly favoring states that already have firm CBD regulations in place — and to use the products in moderation.

There is scant evidence to suggest that CBD itself causes any issues with liver function at low levels. However, it is still important to keep some key things in mind. One of the first things to keep an eye out for is low-quality CBD, which may harm your liver by exposing it to toxins.