Tue. May 21st, 2024
cbd drug interactioncbd drug interaction

Almost everyone is aware of what CBD is and what are the health benefits of CBD. Cannabis users all over the world are curious to know how to incorporate CBD into their lifestyle. Many other wonders to know about CBD & Drug Interactions. Are you?

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Cannabidiol has gained widespread popularity due to its therapeutic health benefits. Research is ongoing as to how effective CBD is and why people are trying it.

Overall, CBD is a well-tolerated and safe cannabinoid to use for general wellness. But before giving it a try, always talk to your doctor. It is crucial talking your doctor about all of the vitamins, supplements, and prescriptions.

Here is a deeper look at why having the conservation matters.

Drug Metabolism & Cytochrome P450 Enzymes

Whenever you take a medication or other substance, your body metabolizes it or breaks it down. Drug metabolism happens throughout the body, such as in the liver and the gut. However, the liver plays a major role in metabolism.

Cytochrome P450 is a family of enzymes that helps in drug metabolism. CYP450 enzymes work by converting foreign substances to easily eliminated particles from the body.

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However, some medications can slow down or speed up the drug metabolism. The change in the metabolism rate can alter how your body processes the medication or supplement you take.

Why Does Cytochrome P450 Matter When it comes to CBD and Medications?


Research shows that CYP450 enzymes involve in the metabolism of several cannabinoids, including CBD. Specifically, CYP3A4 is an enzyme that does this task. During the process of metabolism, CBD interacts with CYP3A4 enzymes.

If CBD is inhibiting CYP3A4, it cannot work effectively to break down medication in your system. The reverse can happen, too. Most medications inhibit the CYP3A4, and if you take CBD with those medications, your body cannot work to process CBD.

Some substances speed up the CYP3A4 enzyme family. If your body is metabolizing a medication too fast because another substance is inducing the enzyme, you may not have enough medication to treat a certain health issue.

Trying CBD Safely While Taking Other Medications:

If you are interested in administering CBD, make sure to consult with your doctor. Healthcare professionals will help you to determine the accurate dosage of CBD under other medications. For some situations, your doctor may examine blood plasma levels.

Also, do not stop taking your medications unless your doctor says it safe.

Keep in mind the other options to incorporate CBD like lotion, creams, and salves as they don’t enter the bloodstream. In contrast, edibles and sublingual oil pass through the digestive system and liver before reaching the bloodstream.

Related – Reading A CBD Product Label

CBD & Drug Interactions Look at the grapefruit warning:


Although research on the potential health benefits of CBD and its interaction with specific medications. However, there is a rule of thumb that can help consumers in the meantime. You can avoid CBD if your medication has a grapefruit warning.

Grape Fruit warning indicates that people taking these medications should avoid grapefruit or grapefruit juice.

Grapefruit warning comes with several types of medications. Check your medications insert information, or ask your doctor.

Types of medication with grapefruit warning:

  • Antibiotics
  • Antimicrobial
  • Antiepileptic drugs
  • Blood thinner
  • Blood pressure medications
  • Cholesterol medications
  • Corticosteroids
  • Erectile disfunction medications
  • Heart rhythm medications
  • Immunosuppressants
  • Mood and pain medications
  • Prostate medications

Safety & Side Effects

Consultation with an expert can make you safely use CBD with other medications. If necessary, your doctor will examine your plasma level before administering CBD.

However, if you are taking CBD with medications, it is crucial to keep an eye out for any potential changes in how the medications or CBD affects you.

Side effects to watch for:

Increased or new medications side effects, such as:

  • Drowsiness
  • Sedation
  • Nausea

A decrease in medication side effect:

  • Breakthrough seizures

Common CBD side effects, such as:

  • Fatigue
  • Diarrhea
  • Change in appetite
  • Weightloss

CBD & Drug Interactions – Talk to Your Doctor:

The final verdict from our side is to talk to your doctor, especially if you have a health condition and are taking medications. Do not stop taking medication to try CBD unless you have the go-ahead from your doctor.

Also, you can avoid taking CBD with those medications that contain grapefruit warning as CBD & these medications inhibit the CYP450 enzymes. However, even if you take these medications, your doctor can formulate a plan that works for you. That way, you can use medications and CBD as therapy.

Overall, CBD is a well-tolerated, safe, and effective cannabinoid to use for some health conditions. Its therapeutic effects work best to alleviate the symptoms of pain, inflammation, nausea, and more.

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By Fiza Arooj

Fiza Arooj is a freelance writer and editior based in Mian Channu, Pakistan. Her writing covers Cannabis, Health, Beauty, and Travel niches. Her work has been published by WibiData, Pythonblogs, Six3, Cannabidiol.Shop, and more.

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