Most CBD users report that taking regular CBD dosage is crucial to get better results. Does consistent results of the same dosage over a prolonged time CBD tolerance? People who take supplements might be familiar with substance tolerance over time. The human body is flexible at adapting to a different substance – lowering its effectiveness over time.
People who administer CBD as a wellness supplement regularly asks about the risk of building tolerance with time.
Continue reading to learn more!
Can You Build a Tolerance to CBD?
Substance tolerance is a common and well-accepted effect. You might have experienced it in your daily routine when you take coffee or tea. If you are a regular user, you need stronger doses over time to experience the same effects as you did earlier.
CBD users take CBD frequently as some take it twice a day while others take it four times a day to meet their needs. If CBD develops tolerance, it should abide by the mechanisms that most supplements use.
Let’s elaborate on why people build substance tolerance over time!
How Does Tolerance Work?
Generally, tolerance is of three types:
- Behavioral – when you become psychologically adapted to substance effects
- Cellular – when you become less responsive to a substance/ compound
- Metabolic – when lower concentrations of reach the target area
You can show the symptoms of these three mechanisms depending on the interaction between body and substance.
Some people develop tolerance a bit quickly, while others take time. Every person builds tolerance differently depending on:
- Genetic structure
- History of substance abuse
- Environmental factors
When it comes to cannabinoids, tolerance is noticeable mostly on a cellular level. With time, the endocannabinoid receptors may become desensitized, meaning they become less enthusiastic about interacting with cannabidiol.
What Happen Inside Your Body When You Take CBD?
Cannabidiol uniquely interacts with the endocannabinoid system. Besides attracting with CB1 & CB2 receptors, it affects these receptors indirectly. Most research studies found that a person cannot theoretically build a tolerance.
CBD uses a relatively different mechanism by encouraging the production of the endocannabinoid and their affinity to bind with cannabinoid receptors. Through this mechanism, CBD assists the endocannabinoid system to maintain homeostasis on all vital processes of the body.
Aside from forcing the endocannabinoid system to become more or less productive, CBD enhances its functioning. Cannabidiol modulates the activity of cannabinoid receptors to ensure it binds with endocannabinoids.
CBD Tolerance vs. THC Tolerance:
Most people opt for THC-rich cannabis products that bind with CB1 receptors in the brain. The affinity of THC with cannabinoid receptors results in a pronounced high. However, regular intake of THC products causes less pronounced effects.
THC tolerance happens on a cellular level. Upon regular intake of delta-9 THC, the cells try to maintain normal CB1 receptor activity by reversing its effects.
On the other hand, CBD does not bind with cannabinoid receptors. Cannabidiol mimics the natural endocannabinoids to stimulate their production and affiliation with cannabinoid receptors.
How Fast Does CBD Tolerance Build?
Generally, a person cannot build CBD tolerance. All individuals have different tolerance thresholds that may change over time. In other words, a person may need more amount of CBD over time due to changes in the endocannabinoid system and overall body chemistry.
Tolerance and its fluctuations depend upon the following factors:
- Experience with CBD
CBD Tolerance vs. CBD Dependence:
Some people associate tolerance with dependence or drug addiction. However, there is a difference between both these terms, such as:
- Tolerance is what you experience when your body becomes less sensitive to a compound over time. For example, how your body builds tolerance to THC and caffeine, among other substances.
- Dependence is when you go through withdrawal symptoms – both physical and emotional. The withdrawal symptoms range from mild to severe, such as headache, mood swings to depression, and heart failure.
Well, fret not! CBD has a good safety profile. In general, it shows minimal to zero side effects such as appetite change, fatigue, and dry mouth.
What Is CBD Reverse Tolerance?
Some research studies found that a person can develop reverse tolerance where less CBD is required to achieve the desirable effects. Also, CBD can reduce the activation of CB1 receptors without desensitizing the endocannabinoid system. The interaction may prove beneficial as it can reduce the side effects of and tolerance forming potential of THC.
Typically, it is difficult to provide a definite answer on the habit-forming potential of cannabidiol. Right now, there are limited research studies to prove this fact.
CBD Tolerance In A Nutshell:
Commonly, people can build substance tolerance over time, but it is not the case with CBD. The unique mechanism of CBD interaction with the endocannabinoid system has made it difficult to understand its tolerance.
If CBD oil is not working for you, your threshold value may have changed with time. Additionally, be sure to buy CBD products from legitimate suppliers for an overall better experience.